The resurgence of stories of the 1986 Chernobyl nuclear plant meltdown—particularly, for subscribers of HBO where the series “Chernobyl” presents incredibly explicit detail of this technological catastrophe—coincides with significant and current tensions concerning approaches to global energy production, defense, and fears of terrorism. What provides formidable sources of concentrated energy can provide immense amounts of power, but can also be used to obliterate targets with sheer force, or poison them by simply “dirtying” with radiation. It is the metallic elements that are called “actinides” that release energy upon radioactive decay, and it is irradiation by these metals—including the well-known uranium and plutonium—that pose serious hazards to most organisms. But it might surprise some that significant research into actinide “chelators”—molecules that can form several bonds with metal ions—has met with some success, particularly with uranium. However, while these molecules could strongly chelate uranium from bone and tissues and exit via urine and feces, they were highly toxic to the kidneys and other body systems; conversely, less toxic versions of chelators were not as capable in sequestering uranium. But in a recent publication (and nicely described in a well-written overview for non-chemists), an improved version of uranium chelator—5LIO-1-Cm-3,2-HOPO—was not only able to more effectively remove uranium from the bones and kidneys of mice, but it could do so when administered orally or intravenously, and even when those doses were delayed. This latter point is significant, since a lengthened window of opportunity to treat victims of exposure might be required, particularly when they cannot access medical or emergency treatment facilities for a prolonged period. While this newly developed chelator has only been tested in mice, it shows promise that humans might soon have rapid and highly effective treatments against uranium poisoning, and someday, possibly other actinides, as well. These developments in chemistry and medicine will be key to ensure that we have the tools in hand to protect populations from accidents and other unanticipated threats.