Researchers last week published in nature key findings linking APOE, specifically the E4 variant, could lead to accumulation of a pathogenic conformation potentially inducing the disease. While APOE has been previously linked this study is the first to identify a specific cause and effect from APOE. The authors took the next step and applied a structural corrector and reported a restoration of APOE and cellular activity. Interestingly, the authors identify a potential reason why it has been so difficult to identify or development treatment options for alzheimers when using mice as models as they do not have amyloid beta production like humans do.