Hear that buzzing? With spring upon us, that ubiquitous high-pitched droning near your ear during a walk in the park or family picnic has conditioned most people to make a reflexive slap to the side of our own heads, often resulting in a bloody smear of insect on your palm and cheek. This isn’t merely a problem for friends or family on vacation, or a local leisurely stroll, but also a serious challenge for American troops deployed around the world. Mosquito feeding has become synonymous with dangerous insect-transmitted diseases, including malaria, dengue, and chikungunya – all of which can have grave consequences on the public, but also can impede military readiness. While there have been traditional technologies to help ward off mosquitoes—bed nets, repellents, and even anti-malarial drugs—these have met with limited success, and existing therapeutics have such significant side effects that soldiers often avoid taking them altogether. New biological technologies such as gene drives that impede mosquito breeding are also being implemented to help control their populations. But even mosquitoes are an integral part of ecological trophic pyramids: feeding fish, birds, and other insects. Here’s where a new DARPA program—ReVector—opens up a tantalizing opportunity to provide a solution that protects the human targets of mosquitoes, and accomplishes it in a non-lethal manner. Humans and other animals emit chemical signatures that cue as a signal for mosquito targeting and feeding, and production of these metabolites are intrinsically linked to the microbes that grow on your skin. A major goal of the ReVector program is to understand the components of the skin microbiome that contribute to mosquito attraction and decipher ways to manipulate these components and reduce the characteristics that make humans identifiable by these vectors. It will take a significant effort to determine the chemical, biological, and microbial mechanisms that contribute to the detection of humans by mosquitoes. But imagine the possibility of applying a simple cream or spray that enables your microbiome to help you become masked from these relentless blood-feeders for days at a time. The development of a solution that is safe for citizens, soldiers, and mosquitoes alike, would be a significant re-vectoring for us all.